It is common practice to combine the shuffle with a lick in the open position. Try the following exercise which alternates between a basic E chord shuffle and a lick taken directly from the previous example. The symbol N.C. means no chord is played.
Now Try applying the principal from the previous example to an entire 12 Bar Blues progression.
The next example incorporates the seventh chord.
Now apply the previous combination of shuffle and licks to a 12 Bar Blues progression.