Probably the most common sound in Blues rhythm guitar is the shuffle rhythm played on two strings. This rhythm pattern uses what are commonly called fifth chords, or power chords. Technically a chord requires three or more notes, but as these two note fingerings are now commonly used in several styles of music it has become acceptable to refer to them as chords. Three popular fifth chords in the open position are A5, D5 and E5, which can work together as chords I, IV and V in the key of A.
Practice changing between these chords until you can play them smoothly and in time. Notice the use of the shuffle rhythm. Use all downstrokes when playing this style.
To complete the pattern for the classic shuffle sound, the third finger is placed two frets up the neck on the same string as the first finger. The same two strings are played as in the fifth chord. Keep the first finger down even when playing with the third finger. This will result in a smoother, more solid sound.
When playing this type of shuffle, it is common to damp the strings slightly with the right hand. This results in a tighter, more chunky sound. Rest the heel of the hand on the strings at the bridge and then pick the strings you want to sound. It may take a bit of practice to get the desired sound, it all depends on the exact position of the right hand and the amount of pressure used on the strings. Here is an example.
Now try applying the right hand damping technique to this 12 bar Blues.